PolyTope® TATX-03 Highlights
PolyTope® – Multi-Ab Cocktails Against SARS-CoV-2 and Variants of Concern (VOCs). Multi-antibody (Ab) cocktails (MACs) that consist of either 4-Abs (TATX-03b) or 5-Abs (TATX-03c). TATX-03b (4-Ab cocktail) has been selected for clinical development. TATX-03c (5-Ab cocktail) shown to illustrate ‘plug-and-play’ for potential future formulations. Each polytopic cocktail is rationally designed to provide enhanced, long-lasting protection by simultaneously targeting multiple epitopes on the spike trimer, thereby engaging multiple mechanisms of action and reducing mutagenic escape risk. [ᵅ Preclinical in vivo efficacy Syrian hamster model; ᵇ Tested against pseudotyped virus; ᶜ Reduced lung viral titers to undetectable levels in (13/15) animals.; ᵈ Roodink, et al. bioRxiv, Jul 2021.; *22-D9 Ab only included in TATX-03c.]
With the ongoing threat of COVID-19 and rising concerns from the frontlines about the effectiveness of existing vaccines and antibody therapies, IPA’s Polytope® antibody cocktail continues to demonstrate promising efficacy during studies conducted by the Talem, even when tested against newly emerged variants. New data reveal remarkable consistency in the ability of the PolyTope® TATX-03 antibody cocktail to retain its potent and complete in vitro neutralization against all variants, as demonstrated with Omicron pseudovirus reinforced with neutralization data against the wild-type parental virus (Wuhan) and all predominant variants of concern.
Pseudovirus Neutralization of TATX-03
Overview of TATX-03b and TATX-03c pseudovirus neutralization screenings towards SARS-CoV-2 and variants of concern (Wuhan-1, Alpha, Beta, Delta, Omicron). Green checkmarks indicate potent neutralization.
The PolyTope® TATX-03 antibody cocktail was developed to target multiple, non-overlapping epitopes on the spike trimer, reducing the risk of mutagenic escape, and facilitating engagement of mechanisms of action that are collectively distinctive from other SARS therapies obtainable to date
Taken together, we use a rich diversity of methods and platforms to increase the chance of converging upon a collection of lead candidates which can be rapidly reformulated and reformatted. This allows for PolyTope® to be continuously updated and optimized in response to emerging disease variants, improving durability of our SARS-CoV-2 therapies and enabling expanded use for novel, emerging, infectious diseases.
Please contact bd@talemtherapeutics.com, with scientific questions regarding our PolyTope® TATX-03 Program.
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